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Since Tramadol is a very popular medication purchased online,
we have configured a listing of drug interactions between it
and other popular medications.

 

TRAMADOL + Cymbalta

Do not take Tramadol and Serotonin norepinephrine reuptake inhibitors together without talking to your health care provider. Serotonin norepinephrine reuptake inhibitors include medicines such as Savella, Cymbalta, Effexor, and Pristiq.
Side effects may get worse if you take these drugs together. This combination may increase the risk of confusion, increased blood pressure or heart rate, loss of coordination, restlessness, sweating, tremor, vomiting, or other serious side effects.

TRAMADOL + Xanax (Alprazolam)

You may feel drowsy or more tired when taking these drugs together. This effect may last for a few days after you stop taking these drugs together. Do not drive or operate machinery until you know how these drugs affect you. If you notice slurred speech, confusion, severe weakness, or difficulty breathing, contact your health care provider immediately. Examples of Skeletal Muscle Relaxants include, but are not limited to, Skelaxin, cyclobenzaprine, Flexeril, Lioresal, Norflex, Robaxin, and Soma.

TRAMADOL + Suboxone (Buprenorphine)

Ask your doctor before using buprenorphine together with traMADol. This can increase the seizure risk if you are taking other opioids. Contact your doctor if you experience extreme drowsiness, shallow breathing, slow heartbeat, extreme weakness, cold or clammy skin, feeling light-headed, fainting, or seizures. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely use these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs.

TRAMADOL + Alcohol

Avoid alcohol-containing drinks while taking medicines that cause drowsiness. Using some of these drugs along with alcohol can lead to serious side effects. You may feel drowsy or more tired when taking these drugs together. Do not drive or operate machinery if you are drinking alcohol-containing beverages. If you notice slurred speech, confusion, severe weakness, or difficulty breathing, contact your health care provider immediately.

 

TRAMADOL + Soma

Using carisoprodol together with traMADol may increase side effects such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience some impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with these medications. Avoid driving or operating hazardous machinery until you know how the medications affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
TRAMADOL+ Flexeril

Talk to your doctor before using traMADol together with cyclobenzaprine. TraMADol may cause seizures, and taking it with other medications that can also cause seizures such as cyclobenzaprine may increase that risk. The interaction may be more likely if you are elderly, undergoing alcohol or drug withdrawal, have a history of seizures, or have a condition affecting the central nervous system such as a brain tumor or head trauma. You should avoid or limit the use of alcohol while being treated with these medications. Avoid driving or operating hazardous machinery until you know how the medications affect you. Call your doctor immediately if you experience seizures while using the medications.
TRAMADOL + Vicodin (Hydrocodone)

GENERALLY AVOID: Concomitant use of tramadol increases the seizure risk in patients taking other opioids. These agents are often individually epileptogenic and may have additive effects on seizure threshold during coadministration. CNS- and respiratory-depressant effects may also be additive. In patients who have been previously dependent on or chronically using opioids, tramadol can also reinitiate physical dependence or precipitate withdrawal symptoms.

MANAGEMENT: Concomitant use of tramadol and other opioids should be avoided in general. Tramadol should not be used in opioid-dependent patients, and use in patients who are chronically on opioids is also not recommended. Tramadol is contraindicated in patients with acute opioid intoxication. Tramadol dosage should be reduced if it must be used in patients receiving opioids. Patients should be monitored for development of seizures and CNS and respiratory depression.
TRAMADOL + Lyrica

MONITOR: Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients.

MANAGEMENT: During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Ambulatory patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

TRAMADOL + Ambien

You may feel drowsy or more tired when taking these drugs together. This effect may last for a few days after you stop taking these drugs together. Do not drive or operate machinery until you know how these drugs affect you. If you notice slurred speech, confusion, severe weakness, or difficulty breathing, contact your health care provider immediately.

TRAMADOL + Adderall

Avoid taking Tramadol and amphetamines like Amphetamine or Dextroamphetamine together whenever possible. There is an increased risk of serious side effects (seizures) if both of these drugs are taken.

 

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